MOTS-c 5mg

MOTS-c 5mg Lyophilized Powder: Mitochondrial Mechanism, Metabolic Research

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide (MDP). Unlike traditional nuclear-encoded peptides, MOTS-c is transcribed directly from the mitochondrial genome. It functions as a metabolic signaling molecule, translocating to the cell nucleus under metabolic stress or exercise to regulate gene expression. By activating the AMP-activated protein kinase (AMPK) pathway, MOTS-c plays a central role in energy balance, cellular resilience, and glucose homeostasis.

Key Features & Technical Specifications

 Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

 Molecular Formula: C_{101}H_{152}N_{28}O_{22}S_2

 Molecular Mass: ~2,174.6 g/mol

 Form & Quality: 5mg lyophilized sterile powder (≥99% HPLC certified)

 Primary Pathway: AMPK Activation & NRF2 Antioxidant Signaling

 Solubility: Soluble in bacteriostatic water or sterile saline protocols

Primary Research Applications & Proposed Benefits

 AMPK Activation & Exercise Mimicry: Activates cellular energy sensors, stimulating glucose uptake into skeletal muscle without changing basal insulin levels.

 Fat Oxidation & Weight Homeostasis: Enhances lipid metabolism and mitochondrial beta-oxidation, preventing diet-induced metabolic dysfunction in model systems.

 Insulin Sensitivity: Improves system-wide glucose tolerance and metabolic flexibility under high-fat or stress conditions.

 Mitochondrial Resilience & Anti-Aging: Promotes adaptive stress responses and downregulates pro-inflammatory cytokines, supporting cellular longevity research.