MOTS-C 10mg
$115.00
Buy high-purity MOTS-c 10 mg lyophilized research peptide (≥99% purity). MOTS-c is a 16-amino acid mitochondrial-derived peptide that activates the AMPK pathway to regulate metabolic homeostasis, glucose utilization, and cellular stress resistance. Ideal for research in metabolic health, exercise adaptation, and longevity science. Fast shipping and lab-tested quality guaranteed.
Description
MOTS-c 10 mg Lyophilized Powder: Mitochondrial Mechanism, Metabolic Research
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide (MDP). Unlike traditional nuclear-encoded peptides, MOTS-c is transcribed directly from the mitochondrial genome. It functions as a metabolic signaling molecule, translocating to the cell nucleus under metabolic stress or exercise to regulate gene expression. By activating the AMP-activated protein kinase (AMPK) pathway, MOTS-c plays a central role in energy balance, cellular resilience, and glucose homeostasis.
Key Features & Technical Specifications
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C_{101}H_{152}N_{28}O_{22}S_2
Molecular Mass: ~2,174.6 g/mol
Form & Quality: 5mg lyophilized sterile powder (≥99% HPLC certified)
Primary Pathway: AMPK Activation & NRF2 Antioxidant Signaling
Solubility: Soluble in bacteriostatic water or sterile saline protocols
Primary Research Applications & Proposed Benefits
AMPK Activation & Exercise Mimicry: Activates cellular energy sensors, stimulating glucose uptake into skeletal muscle without changing basal insulin levels.
Fat Oxidation & Weight Homeostasis: Enhances lipid metabolism and mitochondrial beta-oxidation, preventing diet-induced metabolic dysfunction in model systems.
Insulin Sensitivity: Improves system-wide glucose tolerance and metabolic flexibility under high-fat or stress conditions.
Mitochondrial Resilience & Anti-Aging: Promotes adaptive stress responses and downregulates pro-inflammatory cytokines, supporting cellular longevity research.
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