Receptor Grade IGF-1 LR3 (1mg)
IGF-1 LR3 Receptor Grade 1 mg provides a high-purity, laboratory-verified lyophilized recombinant peptide manufactured under strict quality control standards in the USA. Formulated with 1 mg of pure Long \text{R}^3 Insulin-like Growth Factor-1, this modified analog features an arginine substitution at position 3 and a 13-amino-acid N-terminal extension. Specifically designated as receptor grade, this compound exhibits significantly reduced binding affinity for IGF binding proteins (IGFBPs), allowing researchers to study prolonged, uninhibited receptor-ligand interactions and cellular proliferation dynamics.
Key Specifications
Ā Active Compound: IGF-1 LR3 (Long Arginine 3 IGF-1)
Ā Grade: Receptor Grade
Ā Concentration: 1 mg per vial
Ā Purity Standard: Exceeds 99% (Third-Party HPLC Verified)
Ā Formulation: Sterile Lyophilized Powder
Ā Origin: Manufactured in USA
Ā Classification: Research Use Only
Primary Research Applications
Ā IGFBP Resistance & Extended Half-Life: The structural modification drastically lowers binding to IGF-binding proteins, enabling researchers to observe sustained activation of the IGF-1 receptor (IGF-1R) without rapid metabolic inactivation.
Ā Cellular Proliferation & Protein Synthesis: Widely applied in vitro to study MAPK/ERK and PI3K/Akt/mTOR signaling pathways involved in cell growth, myogenesis, and nutrient transport regulation.
Ā Hyperplasia & Tissue Culture Assays: Utilized in research models measuring satellite cell activation, skeletal muscle fiber recruitment, and metabolic shift mechanics.